LipidRescue® Therapy exerts two very important direct effects on the heart: it improves cardiac contractility (pump function) and reduces ischemia-reperfusion injury (IRI). IRI is the severe tissue damage caused when blood supply returns to tissue after a period of ischemia or lack of oxygen. The reintroduction of oxygen alters cellular metabolism, the by-products of which cause cell damage and can lead to cell death. Myocardial IRI has no specific, reliable treatment available today. LipidRescue® Therapy can have a potential role in improving outcomes in several settings where IRI is at play.