NODO refers to life-threatening overdose of a drug or combination of drugs not in the family of opioids - this means a mu-receptor antagonist like naloxone will not reverse this toxicity. In fact, most NODO lack a specific antidote, presenting a considerable unmet medical need. An effective treatment for NODO, especially those caused by cocaine and other cardio-active drugs holds significant potential for helping patients.
LipidRescue® can reverse toxicity caused by drugs that are fat soluble including many of the drugs involved in severe, or even fatal NODO. The mechanism is widely applicable and can apply to combinations of drugs and situations where the drug(s) is unknown.