NON-OPIOID DRUG OVERDOSE (NODO)
NOTE:
LipidRescue® is an investigational drug; the safety and efficacy of the drug have not been approved or authorized by FDA. LipidRescue® is a proposed proprietary name that is subject to FDA approval.
More information about NODO
How does NODO occur?
- NODO results from intentional or accidental ingestion of excessive amounts of pharmaceutical or illicit drugs, often in combination.
How often does NODO occur?
- The 2011 Drug Abuse Warning Network (DAWN, see link below) found ~2.5M emergency room visits for drug abuse or overdose. In 2018, NODO caused over 20,000 fatalities.
What illicit drugs result in NODO?
- In 2011, roughly 40% (~500,000) of NODO involved cocaine, 36% (455,000) involved marijuana and another 12% (~160,000) involved amphetamines. Each is lipid soluble and LipidRescue® could help treat related NODO.
What pharmaceuticals cause NODO?
- Many drugs involved in severe, or even fatal NODO are lipid-soluble and therefore potentially addressable by LipidRescue®. These include among others antihypertensives (e.g., calcium channel or beta receptor blockers), antidepressants (e.g., tricyclics) and antipsychotics.